activation of camp-dependent protein kinase pka
| PAG Title | activation of camp-dependent protein kinase pka |
| PAG ID | WAG000029 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | G-protein coupled receptors (GPCRs) are one of the largest gene families of sigling proteins. Residing in the plasma membrane with seven transmembrane domains, GPCRs respond to extracellular stimuli that include catecholamine neurotransmitters, neuropeptides, larger protein hormones, lipids, nucleotides and other biological molecules. When a GPCR binds its extracellular ligand, it interacts with a G-protein to transduce a sigl across the membrane into the cellular interior. G-proteins are a heterotrimeric complex containing a Ga subunit with GTPase activity, as well as b and g subunits. Ga can exist in an active state and an ictive state. Ga in the off state has GDP bound and does not activate downstream sigling molecules. When a GPCR is activated by ligand, it stimulates Ga subunits to bind GTP instead of GDP and become active, dissociating from the receptor and from the b/g subunits to activate downstream sigling factors like the enzyme adenylyl cyclase that synthesizes cyclic-AMP (cAMP) from ATP. Ga turns itself back off again with its intrinsic GTPase activity, hydrolyzing GTP to GDP to become ictive again. |
| Species | Homo sapiens |
| nCoCo Score | 3,613 |
| Base PAG ID | WAG000029 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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